Zafirlukast is contraindicated in men and women with a background of hypersensitivity reactions on the Energetic drug part plus the inactive compounds throughout the formulation, including povidone, lactose, titanium dioxide, or cellulose.

Liver Damage. Liver harm, also called hepatotoxicity, can take place when using zafirlukast. Phone your wellbeing treatment supplier instantly Should you have any of the next indicators of liver injury.

Nonetheless, significant will increase in eosinophil concentrations can result in really serious adverse effects, like swelling (inflammation) of your lungs or blood vessels. Get in touch with your health and fitness care provider without delay if you have any of the following signs of those ailments.

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Test with your well being care professional if any of the subsequent Negative effects keep on or are bothersome or In case you have any questions about them:

The imply prothrombin time enhanced by close to 35%. The pharmacokinetics of zafirlukast were unaffected by coadministration with warfarin.

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Several other medicines may perhaps change the blood amounts of zafirlukast, and vice versa. Notify your well being care provider about all medicines that you simply consider or have not too long ago taken.

The pharmacokinetics of zafirlukast are close to linear over the range between 5 mg to 80 mg. Steady-point out plasma concentrations of zafirlukast are proportional into the dose and predictable from solitary-dose pharmacokinetic knowledge. Accumulation of zafirlukast while in the plasma adhering to twice-daily dosing is approximately forty five%.

Allergic reactions to Elements. People who are allergic to any of the following should not take zafirlukast.

Evaluate the effectiveness of zafirlukast therapy in managing asthma signs and symptoms and strengthening lung purpose, monitoring treatment method response, and modifying the treatment method system as vital.

Monitoring for signs of allergic reactions relevant to the medication, eosinophilic vasculitis, neuropsychiatric problems, and hepatic dysfunction

Zafirlukast (brand name title 3-Deazaneplanocin A Accolate) was the 1st cysteinyl leukotriene receptor antagonist accepted in The usa. Now it is permitted in all kinds of other nations around the world less than other manufacturer names.

The empirical method is: C 31H 33N 3O 6S Zafirlukast, a wonderful white to pale yellow amorphous powder, is almost insoluble in drinking water. It truly is a little bit soluble in methanol and freely soluble in tetrahydrofuran, dimethylsulfoxide, and acetone.